Thompson was part of a large unit commanded by John Stafford, that was attempting to drive the invading Pandoran soldiers out of New Malaga, during the invasion of Mythos in late 2617. She lost her fiancée when the unit was ambushed. The unit was fragmented and eventually reduced from its initial 21 members, to just 4. Thompson survived along with Stafford, Smith and Milligan.

Later, she fought alongside Chaz Koonan and Estelle de Winter during the battle of Hunter's Square, helping to drive the enemy away. She later went on to explain to Estelle and Chaz about how the soldiers they were fighting were all infected with nanomachines.