The Pandorans are emotionless warriors who possess far superior skills to ordinary human soldiers. They are stronger, faster and more combat efficient, as well as being quick learners and incredibly fast healers.

The origin of the Pandoran force remains a mystery (or, to those in the know, a closely guarded secret). Their first recorded appearance occurs around 2612, when they participated in the Imperial Civil War, fighting alongside the Imperial Senate's forces against the Crowned Emperor. Though their numbers were small to begin with, they quickly grew and by late 2616, they had destroyed much of the Imperium. They took the Kethlan system around November 2616. They are led by Jason Zackaria, who acts as the Fleet Admiral and supreme commander.

In early 2617, the Pandorans intercepted Dragon in jump and hijacked it, slaughtering the crew but sparing Anthony Hawke, the acting captain. In June of the same year they engaged allied CSN and UNF forces in the Aster system, where they made short work of their adversaries.

During the incident at Arlos starport, several of the soldiers demonstrated a strong resilience to gunshot wounds, as well as strength and fighting advantages over their opponents.

They follow the orders of Jason Zackaria to the letter and put his safety above all else, as they demonstrated when the admiral was spaced from Ifrit's bridge. The group immediately ceased their attack on Griffin and the White Knights, for fear that a stray shot might strike him.

Towards the end of 2617, the Pandoran army had commenced its push beyond the Mitikas Empire, striking a number of boarding independent star systems, including Coyote. Once again lead by Jason Zackaria, the army succeeded in tracking Ifrit through jump, intercepting the vessel and forcing it back to normal space. Originally intending on taking command of the ship, they were thwarted by Christopher Hail, the captain, who ditched it in the Tanis Sea on Mythos.

During the invasion of Coyote, the soldiers once again displayed superhuman feats, as well as showing no mercy towards their opponents, once more repeating the mantra of taking no prisoners and sparing no lives. They did, however, make two exceptions to this rule: capturing Kelly Taylor and Enrique Todd and leaving Simon Dodds to the mercy of Jason Zackaria.

It was revealed to Estelle de Winter by Edie Thompson that the Pandoran soldiers were in fact citizens of Mitikas, who had been infected by specifically-crafted nanomachines, created by the Imperial Senate (hence, The Senate's Mistake). Having spent a considerable amount of time in Mitikas during the initial uprising of the Pandoran forces, Chaz Koonan was already quite aware of the threat they posed to the galaxy, as well as their strengths and abilities. His own personal situation, however, forced him to remain tight-lipped about the matter, until the Helios Confederation could formulate a plan of action for dealing with them.

Later, Natalia Grace confirmed that the Senate had created the nanobots in response to their ongoing war against the Crown Emperor Adam Lorenzo III. The bots not only granted their hosts superhuman abilities (such as advanced healing, strength, reactions and a hive mind), but also made them completely loyal to the original Senate and to their cause (The Mission).

Their original instructions had been to eliminate all opposition to the rule of the Imperial Senate. However, these instructions were so broad in depth that when the original senate were killed during the war, the infected were left with no one to order them to stop after they had sacked Kethlan and taken the Seat of the Emperor. They therefore opted to continue carrying out these instructions, seeing the Mission as incomplete. They subsequently turned their attentions to the independent worlds and the Helios Confederation.

As of the end of 2617, the strength of the Pandoran army was approximately 20 billion soldiers. In response to the extreme danger of entering into an unwinnable war against the Pandoran Army, the independent worlds and Confederation launched Operation Sudarberg.

It failed.