Weathers participated in Operation Menelaus as a member of Griffin's comms teams. After the fall out of the battle in the Aster system, she took the post of head of communications of the bridge, following the death of Lieutenant O'Donnell.

As with Ali Liu, Karen Weathers transferred to a new vessel during Griffin's lengthy repair and renovation period, returning her original post as soon as the carrier was cleared for duty. She acted once more as communications officer on the bridge, going with Griffin to the Coyote system to search for the White Knights.

When it was discovered that the Pandoran forces around Mythos were somehow masking their vessel signatures (and declaring themselves friendly) Weathers was charged with working with a number of UNF teams to decipher the cause. She eventually uncovered a fault in the radar systems that was being exploited by the Enemy and oversaw the creation of a software hot-fix.